datum (n=1)<p>"SARS-CoV-2 spike RNA- and SARS-CoV-2-related inflammation persist in the epipharynx for more than six months post infection. Although no expression of the SARS-CoV-2 spike protein in the epipharynx was evident in these patients with long COVID, genetic analysis revealed activation of [...] the SARS-CoV-2 signalling pathway in epithelial cells, B cells, and pDCs. This aligns with theories that <em>even nonactive viral fragments may possess biological significance</em>. This persistence of inflammation, identified for the first time at the genetic level, highlights the epipharynx as a critical site for continual immune responses in long COVID patients, suggesting that residual viral antigens may contribute to the chronic symptoms experienced"</p><p>"After the administration of EAT [epipharyngeal abrasive therapy] once a week for 3 months, the expression of viral RNA disappeared in patients 1 and 2. Patient 3 presented a substantial reduction in viral RNA expression; although complete clearance was not achieved, a marked decrease was observed."</p><p>"observed dysregulation of immune and ciliary pathways" - might explain the chronic nonsmoker cough that seems more common now</p><p>"These findings suggest that T cells still play a subtle role in the immune dysregulation observed in patients with long COVID. Collectively, these findings indicate that interactions among pDCs, B cells, plasma cells, and T cells contribute to the chronic inflammation and immune dysregulation characteristic of patients with long COVID"</p><p>"In the pre-EAT state of long COVID Patient 2, the tissue surface was predominantly covered by ciliated epithelium (Cluster 7). In contrast, following treatment, the ciliated epithelium was no longer observed, and a new cluster of squamous epithelial cells (Cluster 12) emerged"</p><p>"EAT effectively eliminates the inflamed ciliated epithelium in patients with long COVID and induces the formation of squamous cells with high barrier function"</p><p><a href="https://www.nature.com/articles/s41598-025-92908-7" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41598-025</span><span class="invisible">-92908-7</span></a></p><p>thanks <span class="h-card" translate="no"><a href="https://mastodon.social/@MEActNOW" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>MEActNOW</span></a></span> </p><p><a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARSCoV2</span></a> <a href="https://zeroes.ca/tags/epithelium" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>epithelium</span></a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsNotOver</span></a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidCompetent</span></a> <a href="https://zeroes.ca/tags/CovidConscious" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidConscious</span></a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AirborneAware</span></a> <a href="https://zeroes.ca/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a></p>